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Type 2 diabetes is a metabolic disorder in which the body cannot produce sufficient amounts of insulin and/or cannot process insulin adequately. If left untreated diabetes can damage many organs in the body, including the heart, kidneys and eyes.

Western lifestyle associated with obesity, lack of exercise and high fat diets contributes to what is now recognized as a diabetes "epidemic". The global incidence of diabetes is rising astronomically as developing countries adopt western lifestyles. This has contributed to an exponential growth in childhood type 2 diabetes. In the year 2000, there were an estimated 171 million individuals afflicted with diabetes worldwide and 16 million in the US alone. There is an expectation that the number of diabetic individuals world wide will rise to 366 million (see Wild et al., 2000 Diabetes Care, 27:1047-1053).

Since the "cure for diabetes" has proven elusive, new therapies administered alone and in combination are an important focus for pharmaceutical companies, regulatory authorities and health-related organizations worldwide.

We believe that Enzo's candidate drug compounds, that have been shown to lower blood glucose in animal model systems of diabetes, show considerable promise as a therapy for diabetes.